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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

国家卫生健康委员会在上周五的一场新闻发布会上表示,2017年中国各高校共出现3077例新增艾滋病毒感染病例。
Chinese cellphone maker giant Huawei expects its smartphone shipments to grow 29 percent year-on-year to reach 139 million in 2016, compared with an estimated global average shipment growth of 0.6 percent.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中,以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。
That was true, too, of “Mad Men” on AMC. which in its seventh season has all but exhausted its characters and its 1960s setting, but is still keeping viewers guessing about the end, which won’t air until next year. “The Sopranos” ended ambiguously. “Breaking Bad,” put an end to Walter White. Now, the next television mystery looming ahead centers on Don Draper’s last moments, dead or alive.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

其中还出现了一些长期霸榜的易泄露密码,出于某些原因,网友们一直热衷于使用这些密码。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Matthew McConaughey and Jared Leto both won for their startlingly gaunt performances in the Texas HIV drama 'Dallas Buyers Club.' Leonardo DiCaprio, a nine-time Golden Globe nominee, won his second Globe for best actor in a comedy for his uninhibited work in 'The Wolf of Wall Street.' He thanked director Martin Scorsese for his mentorship ('Wolf' is their fifth film together) and for 'allowing me to stalk you to make this movie.'

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Recipient: Lindsay Lohan
IE’s online MBA consistently attracts high-calibre students. Half of IE’s alumni were senior managers when they enrolled, the highest proportion among ranked schools at that stage. Three years after graduation they were earning the highest average salary at $179,000, about $30,000 more than the next highest earners — alumni from Olin Graduate School of Business at Babson College.
He failed to do so and Presti smartly moved on while he could still recoup some value.
事发时,Lecent正与其他年轻人一起在Finch大道,Martin Grove路附近的一家酒吧,她被一颗子弹击中,抢救无效死亡。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 2013中国半导体照明产业数据发布
Perspective

Trends and targets in antiviral phototherapy

3.人工胰腺
The worst of 2015
4. Outsourcing placement services.
WTF.3: I'm Bigger Than You Think

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

So here are the main items to take into consideration if you’re trying to develop a business platform. These elements constitute will support a smart strategy for any new enterprise:

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

当其他同龄人每天乖乖去上学的时候,她已经出来养家糊口四年了,她不得不快速成熟起来。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

The new data released yesterday represent the first snapshot of global trade for 2015. But the figures also come amid growing concerns that 2016 is already shaping up to be more fraught with dangers for the global economy than previously expected.
精准加力补短板。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Foss 还指出别人的推荐信有时间标记。如果你一周之内有五个新的赞那样看起来会很可疑,这些赞不像是真心的,好像你在刷好评,让别人说你好。
On Monday night, Ankara confirmed that the Dutch ambassador would not be welcome to return to Turkey.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

['v?ksi:n]
Yes. There are plenty of positives: earnings, economic growth, and US tax cuts. But they are already known. Stocks look ridiculously expensive by historical standards, but that tells us nothing about short-term moves. Ultimately, it comes down to liquidity, which has driven markets since they emerged from the crisis in 2009. If all goes according to plan, central banks will be decreasing their balance sheets, and removing liquidity, by the end of 2018. If they go through with this, the odds are that the S&P will stall. But even a tiny tremor could make the bankers blink. Expect the momentum to continue.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

安娜上班的地方位于富人区的一家购物中心的车库,她抱怨道:“我去上班的路上要多花费一小时,但我却得不到一个现场看球的机会。“
engaged
还记得《类人猿行动》吗.这是一部被众人忽略的2016年早些时候的电影,由杰米.多南和斯里安.墨菲担任主演,讲述了对希特勒身边的三把手、党卫队将军莱因哈德.海德里希进行的一次失败暗杀。《行动代号:猿人》也尝试讲述这一故事,杰克.莱诺和奥康奈尔将在片中饰演密谋的士兵,而罗莎曼德.派克和米娅.华希科沃斯卡是他们片中的感情对象,杰森.克拉科则饰演他们的刺杀目标。
紧随Fitbit和谷歌眼镜(Google Glass)之后,许多公司开始蜂拥进入这一市场,带来了许多装有感应器的臂章、服饰以及眼镜。这个领域现在炙手可热,但最早使用这些设备的人们似乎都在等待那个时刻,让他们不再显得特立独行。(你知道的,谷歌眼镜的粉丝们现在有了个专门的贬义称呼“Glasshole”。)

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

On questions 10 and 11, if you circled 0, enter 4; if 1, enter 3; if 2, enter 2; if 3, enter 1; if 4, enter 0.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

el[=elect选择]+ite表名词,“人或物”…选出的人物→社会精英
今年最令人惊喜的消息还包括油价下跌。经济学家对油价下跌的经济影响也是见仁见智,一方面认为消费者因此节省了不少油钱,一方面则认为这种趋势会影响石油的开采钻探活动。但大家普遍认为这会影响小型车和混合动力车的销量。油价下跌加上车价过高,使得凯迪拉克公司的电动轿跑ELR稳居2014年最不受欢迎的车型“宝座”。11月份,这款售价高达8万美元的电动跑车只卖出了155辆。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

“trustno1”(不相信任何人)毫无疑问也上榜了,排名第25。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

如果你是一个工薪阶层的白人,担心这个充满国际性的新世界会摧毁或贬抑你所珍视的身份认同,那么你并没有一种在文化上能够被接受的方式,去阐明自己内心感受到的危机。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

她的设备使用了碳纳米管来检测铅的存在。据报道,数千个美国供水系统都有铅污染的问题。
2016年,中国电影票房经历了一次令人震惊的调整,从2015年的48%大幅下降到3.7%。
Oklahoma City GM Sam Presti, no stranger to deadline deals, pulled off a clean win bysending Cameron Payne, Joffrey Lauvergne and a second-round pick to Chicago in exchange for Taj Gibson and Doug McDermott.
['pr?p?ti]

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

预计将有8900多万企业退休人员和1700多万机关事业单位退休人员从中受益。
Are Some Molds Dangerous?
然而,至少有两名哈佛教授对取消入学资格的做法表示质疑。哈佛大学法学院荣誉教授艾伦?德肖维茨告诉《卫报》,学生们因互相之间“开非常恶劣的玩笑”而失去哈佛的入学资格,这样的“惩罚太苛刻”。
Capsized ship righted
He failed to do so and Presti smartly moved on while he could still recoup some value.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

So, before the world gets the better of you and slaps a title on your forehead, create a unique manifesto of what you think you are.
‘Hackers are using common terms from pop culture and sports to break into accounts online because they know many people are using those easy-to-remember words.’

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

In a blog post announcing the deal, Mr Cahan said although mobile devices were shifting our daily routines, “most articles and web pages were formatted for browsing with mouse clicks. The ability to skim them on a phone or a tablet can be a real challenge – we want easier ways to identify what’s important to us.”

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Manufacturing has held up better, with profits growing 6.5 per cent, while profits from utilities such as electricity, heat and water grew 17 per cent, boosted by lower energy prices.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 楼市健康发展须及时除“噪”
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

在收入最高的大学毕业生中,科学和工程领域占据了主导地位,其中软件工程、生物科学和电子信息工程是最赚钱的专业。
n. 文件,公文,文档
Many successful entrepreneurs started later in life. J. K. Rowling (Harry Potter author), Julia Child (chef), and Sam Walton (Wal-Mart) all started their wildly successful brands after they were comfortably along in their lives. Having the experience that comes with age can give you a unique outlook on your business. Life experiences bring depth that the most educated young adult, by his or her nature, is less able to foresee.
时隔多年,贝尔蒙特如今已是一位白发苍苍的老人。没能现场观看1950年世界杯的决赛,他从不感到后悔。那次决赛过后没几天,他的母亲就去世了。“我当时决定放弃观看比赛的机会,事实证明这样做是正确的。”他对记者说。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

The fastest-rising sector is apparel, driven by Nike in sportswear as people pay more attention to health and fitness, and Zara, whose fast fashion is becoming increasingly popular in China.
Most female participants were between 19 and 23.
沙特阿美(Saudi Aramco)会在外国公开上市吗?
根据中国海关的数据,10月铁矿石进口量较上月环比下降12.3%,同比下降4.9%,而煤炭进口环比下降21.4%,同比下降30.7%。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 盘点:我国卫浴行业发展四大亮点
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

In China, there were still 43 million people in rural areas living in poverty at the end of 2016. The country aims to help all of them out of poverty by 2020.
“我认为随着社会变得更多元化,未来这个情况会在一定程度上得到改善。不过这需要一定的时间。”

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

pro向前+duct引导,带来+ive→生产的;多产的
For now, occasional high-ticket deals such as the Dah Sing Financial Centre and the purchase of a HK$2.1bn luxury house on the affluent Peak, come amid wider pessimism about the sector. The office sector showed the most activity in the first quarter this year, but this still translated into only eight deals in total, according to CBRE.
Iron ore imports fell 12.3 per cent by volume in October from the previous month and 4.9 per cent from the same month a year earlier while coal imports were down 21.4 per cent from September and 30.7 per cent from a year earlier, according to Chinese customs data.
During last year's LFW, there were 250 anti-fur protesters, The Guardian reported, and a show in February saw an activist storm the stage at a Mary Katrantzou show.
科学家周日表示,2013年,全球温室气体排放量增加了2.3%,达到历史新高。这个最新迹象表明,在控制全球变暖方面,国际社会的努力仍远远不够。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

迪皮卡 帕度柯妮
在接受《第一财经》采访时,中国建设银行(CCB)董事长提到,中国各银行面对的最大挑战在于不良贷款不断上升。
Skin has the thankless job of coating and protecting your whole body, making it your most easily damaged organ. When you burn or rip off a stretch of skin, your main option right now is to graft some back on from elsewhere on your body. But an effective synthetic replacement skin may not be that far off, thanks to research from Stanford scientists.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 根治“房闹”须坚持“房住不炒”
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

2. Wells Fargo
Amazon founder Jeff Bezos rose to No. 3 on the list for the first time, thanks to the jump in in Amazon shares, which boosted his net worth to $72.8 billion.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

The Belty is great that it uses technology to track fitness, water intake, and posture, but for $395, you might be better off getting the same in a stylish smart watch or activity tracker.
Obama won the second to put himself back in the race. Although he also won the third, foreign policy is not a major concern for voters and it is unlikely to result in any major poll swings.
中国的全国居民消费价格指数(CPI)和工业生产者出厂价格指数(PPI)仍很温和或处于收缩区间,但上月都出现了些许回升迹象。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 个性化卫浴讲走红市场
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

日食
7. How to get a flat stomach
欧洲出现了债务危机。日本面临自然灾害。曾经是全球亮点的新兴市场也失去了光芒。近来意大利、埃及和泰国等国频现政治危机,这或许表明全球市场可能将出现新一轮动荡。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Bottoms Up is the revolutionary new way to serve beer. The Bottoms Up system saves time, eliminates waste and awes customers!

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
From the themed collection: 从O2O到S2B,家居零售模式悄然演进
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

The swap is due largely to the major security breach at software company Adobe in October which affected tens of millions of users.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

年龄:53岁
Such claims are unlikely to go away, though. John R. Christy, an atmospheric scientist at the University of Alabama in Huntsville who is known for his skepticism about the seriousness of global warming, pointed out in an interview that 2014 had surpassed the other record-warm years by only a few hundredths of a degree, well within the error margin of global temperature measurements. “Since the end of the 20th century, the temperature hasn’t done much,” Dr. Christy said. “It’s on this kind of warmish plateau.”

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

节目28 歌曲《留声2012》①《滴答》(表演者:侃侃、李晨)②《我的歌声里》(表演者:曲婉婷、杜淳)
中国12月生产者价格指数(PPI)同比下滑3.3%,为自2009年9月以来最大降幅。矿业价格下跌13.2%,原材料价格下跌6.4%。
“五位一体”总体布局:经济建设、政治建设、文化建设、社会建设、生态文明建设
4.《欲望都市》掀起纸杯蛋糕热

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

追踪中国服务业增长的财新PMI指数将于下周二发布。
8. Experienced Better Cognitive Performance With Bare Feet

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

8.触感人造手
Debrecen is Hungary's second largest city after Budapest, and the heart of low-cost Hungary.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

斯科特的发言人丽贝卡·凯利告诉《人物》杂志:“显然这位年轻的佛蒙特人对服务很感兴趣,任何人提出的想法想让佛蒙特成为一个更好的地方,都能。”

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 刘肖:万科不做中年油腻男
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

美国电话电报公司
201103/129769.shtmlEveryone tells a white lie on occasion, it’s just a question of why. Some white lies save relationships, some ease a hectic situation, and others buy us time. We all do it, so there is no reason to deny it. As long as we aren’t hurting others or breaking the law, these innocent lies can make life more pleasant. Most of these white lies only stretch aninterpretation of what the truth actually is anyways. Here’s a list of the 10most common white lies and why we tell them.
calculation
They're the top three most unaffordable housing markets in the world, according to the 13th Annual Demographia International Housing Affordability Survey: 2017, published recently.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

FlightAware, well known among travelers for its flight tracking app, calculated arrival delays for 18 major and regional U.S. airlines over the Thanksgiving and winter holiday (Christmas through New Year’s) travel periods, as defined by the Transportation Department, from 2010 through 2012.
1. 三菱。品牌喜爱度:-12%/排名:360

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

玛戈特·瓦尔斯特伦(Margot Wallstrom)
China is spending heavily on renewable and nuclear energy as it tries to slow the growth of coal, but despite those efforts it has become by far the largest emitter of greenhouse gases. Its emissions of 10 billion tons a year of carbon dioxide from the burning of fossil fuels and cement manufacturing are almost twice those of the United States, though emissions per person are still far higher in the United States.
达奇斯说:强大的财务性能和一系列新的特性使得邻客音成为2012年吸引用户的公司。这样的吸引力有助于公司在2013年从专业的业务网络转向活跃的交流平台。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 东方集团彻底退出建材零售业
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

谷歌的品牌价值现在超过了1090亿美元,比苹果公司要高大约20亿美元,这使其成为了全世界最赚钱的公司。
美国各地许多餐馆和商店星期三向美国退伍军人提供免费服务或优惠,以纪念一年一度的退伍军人节。
在007电影主题曲榜单上,《女王密使》的主题曲获得荣誉推荐。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

祝你享尽新年佳节的快乐和新年的礼品。
娱乐时尚:性感林赛罗韩大"血拼"

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 苏州将加快培育发展住房租赁市场
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

单词embrace 联想记忆:
据斯派克回忆,一天,拍摄工作结束后,另一位编剧詹妮弗·克里滕登在走廊叫住他,问:"你一定要这样吗?你确定这样不会毁了朱莉娅的前程吗?"考虑到当年朱莉娅凭此剧获得艾美奖,我们不妨说这场舞戏其实让这位女演员在演艺事业上更进了一步。为了怀旧,您不妨抽空再去回顾一下伊莱恩和她著名的"伊莱恩舞步"。
1. The 2012 Ig nobel Psychology Prize

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

While the real Rain Man never counted cards, his mental abilities were just as unbelievable. Kim Peek was a uniquely talented savant who possessed a nearly perfect memory. Among his many skills, Peek memorized every road on the map, the composers and dates of countless songs, and incredibly detailed historic facts. After Rain Man, he spent his life touring the country and campaigning for the disabled, to the delight of many who were able to witness his unique gift in person.
China had a full-year GDP target of “around 6.5 per cent” for 2017.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

openness
A panel of eight WardsAuto editors evaluated 44 engines among all vehicle types during October and November in the course of their daily commutes and weekend activities in and around the Detroit metro area. Engines were rated according to a wide range of characteristics including horsepower and torque, fuel economy, noise, vibration and harshness characteristics, technology and how they fared against competing powerplants.
1. Discipline them: Of course disciplining our children is a given in any home. But we need to ask ourselves if we are disciplining our children properly? Who

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

那些具有3年驾驶经历,无重大交通事故、危险驾驶、吸毒、酒驾记录的司机将可参加网约车考试。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 2015年建材行业大事记:去产能
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

时间:2011-03-28 编辑:beck
台湾电影无缘2012奥斯卡最佳外语片

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 消费升级助推中端酒店大提速
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

The Warriors played pre-season games in China in 2013 against the Los Angeles Lakers, but it will be the first time the Timberwolves visit China.
你翻上去找第十二条,然后默默地笑自己....

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 湖北陶瓷行业有产量无品牌很尴尬
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Businesses can benefit in other ways too. Craig Rollason, business analysis manager at National Grid, says he has improved his coaching skills by mentoring a Teach Firster.
[.reidi'ein]

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Five schools from five different countries are ranked for the first time. Singapore’s Lee Kong Chian School of Business is the highest new entrant coming straight into 36th place. Canada’s Queen’s Smith School of Business registered the best progression, climbing 32 places to 67th.
Acrobatics “Ice And Fire” (Zhao Li and Zhang Quan)

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

答:这是我第一次去旧金山。非常美丽的城市。到那儿的第一天我们就去看了金门大桥。海湾的景色真是让人愉悦啊。我在日本每次看电影,这个城市和这个桥都要被毁一次。但我从不知道这个城市亲眼看的话居然有这么美。下次再来可能就没机会看这座桥了,所以我很高兴这次能看到。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

在此次颁奖典礼上,麦肯锡全球董事总经理鲍达民(Dominic Barton)在典礼上还颁发了“布拉肯贠尔”青年商业作家奖(Bracken Bower Prize for young business writers),获奖者为克里斯托弗克利尔菲尔德(Christopher Clearfield)和安德拉什舠尔奇克(András Tilcsik)。他们计划出版的图书将会探索企业如何能够管控发生灾难性失败的风险。该奖项面向35岁以下作者,专门颁发给那些探讨增长所构成的挑战和机遇的商业图书计划,奖金为1.5万英镑。
2010年中国的计生政策将发生变化吗?
intentionally
Apart from India, other BRICS nations -- Brazil, Russia, China and South Africa -- cut down their holdings of American government securities.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

[slu:]

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

影片评价极高,演技也大获好评,尤其是故事的主人公——那些孩子们,以及汽车旅馆经理的扮演者威廉?达福。
Kobe Bryant
麻省理工学院斯隆管理学院(MIT Sloan School of Management)教授迈克尔?库苏马诺(Michael Cusumano)表示:“我曾经认为乔布斯是不可取代的,而且这在一定程度上是个事实。但乔布斯的精神依然留存在苹果内部,而且公司正围绕着一种不那么对抗性的文化组织在一起。我们应为此给予蒂姆赞扬。”

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

As E.E. Cummings rightly said, "To be nobody but yourself in a world which is doing its best, night and day, to make you everybody else means to fight the hardest battle which any human being can fight; and never stop fighting."
斜着头,怒目,像受到惊吓的狗狗那样

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

China's online retail volume is expected to outperform the rest of the world by reaching four trillion yuan (618 billion USdollars) this year, Commerce Minister Gao Hucheng said Sunday.
今年领跑美国股市的标普500公司的行业组合有些奇特,出现了一些令人意想不到的黑马。就算基金经理预见到了医疗保健行业今年将上涨27%,难道他们也能猜到公用事业行业将位列第二,上涨23%?不大可能。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

引人注目的是,在首次上榜的9所学校中,亚利桑那州立大学(Arizona State University)的WP凯瑞商学院(WP Carey School of Business)成为首次参与此项排名的美国学校,排在第82位。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 卫浴行业黑幕盘点,你中招了吗?
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

2. Mobile overtakes the web.
A Times reporter, Denise Grady, went inside an operating room to observe an experimental technique to treat severe spina bifida in a 24-week-old fetus. The doctors performing the surgery hope it will result in superior outcomes for children born with the disorder. Their first 28 surgeries have seen good results so far. Jan. 14 is the due date for the mother who was the subject of the article.
第二晚(12月9日)的苏富比(Sotheby’s)拍卖会共拍得2260万英镑(含佣金),比佳士得前晚的表现要好得多,不过也只是略高于2180万英镑(不含佣金)的最低估价。44件拍品中有15件流拍,比例达34%。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

轮滑看起来有点像常规的单排轮滑鞋,不过轮滑的轮非常大,尺寸大小跟自行车车轮差不多,看起来像是溜冰鞋,滑雪板和自行车的合体。最近一家名字叫作战车溜冰的公司声称,他们已经有了一些独特的想法——战车轮滑。根据该公司所说,这种轮滑是"革命性的新轮滑产品"。这是一场改革吗?也许是吧,他们至少在改进设计。这是发明吗?不是的。第一双轮滑早在142年前就已存在 。
Never accept the job immediately. Say you need to think about it overnight. Once you sign on the dotted line there's no room for negotiation.
An earlier plan by activists and the US-based Human Rights Foundation to send 100,000 copies of the film in January was postponed until after last month's Lunar New Year.
摩根大通公司下滑至第4名,其总综合得分位居中国农业银行之后。去年名列前10强的两家欧企——荷兰皇家壳牌和汇丰控股,今年仅分别排名11名和14名。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

4.阿迪达斯。品牌喜爱度:35%/排名:25
据悉,这个女孩来自上海,在两个月间每天都通过她妈妈的手机和银行卡,给这名男子网上支付1900元到9500元不等。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Who is hosting the 2014 Oscars?
PBS' 'Vietnam War' series receives a special award.
去年年末,世界卫生组织宣布,寨卡病毒不再是全球紧急公共卫生事件。然而,人们才刚刚开始认识到这种病毒对婴儿及其未来几十年生活的影响。在巴西东北部,人们首次发现了病毒与小头畸形等出生缺陷之间的联系,家庭竭力为患病婴儿提供最好的生活。研究人员希望通过研究在巴西出生的一对双胞胎,来寻找病毒对胎儿影响的线索。这对双胞胎中,一个有出生缺陷,另一个没有。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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补救办法: 做预算。 如果你不能估算需要多少钱才能过上令你感到舒适的生活,你就无法确切地知道为了1万美元薪水而换工作是否真的划算。在比较新、旧工作时,列出各自的优缺点,这会对你很有帮助。如果新工作只是薪水更高一点,那么你可以比较下这个工作是否要求更长的工作时间和完成更多的工作任务。请记住,调查表明:年收入在7.5万美元以内,幸福感会随着薪水的增加而增加,但是一旦薪水超过这个水平,幸福感的增加便不再明显。因此,如果你认为薪水增加到8.5万或9万美元会使你更加快乐,这时你或许应该着手解决生活中那些与金钱无关而引起的不快乐。
2013 Rank: 12

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